The Washington Nationals travel to Fenway Park on Monday, June 29, to open a three-game interleague series against the Boston Red Sox. The opener features veteran right-hander Miles Mikolas taking the mound for Washington against left-hander Ranger Suárez for Boston. Based on the current pitching matchup and recent form, the Red Sox enter the series opener with a noticeable edge.

If you’re looking for the best MLB betting picks for June 29, this matchup offers value on the moneyline, total, and player props.

Nationals vs. Red Sox Starting Pitchers

The Nationals are expected to start Miles Mikolas (2-6, 5.24 ERA). The veteran has struggled to find consistency throughout the 2026 season, allowing plenty of contact while posting a 5.24 ERA. Although Mikolas is known for limiting walks, he has been vulnerable against lineups capable of stringing together extra-base hits, making Fenway Park a difficult venue for this assignment.

Boston counters with Ranger Suárez (3-3, 2.83 ERA), who has been one of the Red Sox’s most dependable starters this season. The left-hander has recorded 84 strikeouts while consistently pitching deep into games and limiting baserunners. His ability to generate weak contact and induce ground balls makes him an ideal fit against a Washington lineup that has been inconsistent against left-handed pitching.

Best Bet: Red Sox Moneyline

Boston has the clear advantage entering Monday night’s contest. Suárez has significantly outperformed Mikolas this season, and the Red Sox should benefit from playing at home after closing out a strong weekend series. Boston’s offense has also shown signs of improvement, producing timely hitting against quality opponents.

Washington has remained competitive this season, but Mikolas has struggled to consistently keep opposing offenses in check. Facing a disciplined Red Sox lineup at Fenway only adds to the challenge.

Best Bet: Red Sox Moneyline

Best Total Bet: Under 8.5 Runs

Despite Boston’s offensive potential, this game still projects as a relatively low-scoring matchup because of Suárez’s consistency. The Red Sox left-hander has done an excellent job preventing big innings, while Mikolas is capable of limiting damage when he avoids home-run trouble.

If both starters reach the sixth inning, the under has strong value, especially with two capable bullpens available late in the game.

Pick: Under 8.5 Runs

Best Player Prop

Ranger Suárez Over Strikeouts

Suárez has consistently generated strikeouts throughout the season and faces a Nationals lineup that can struggle against quality left-handed pitching. If he works six or seven innings, he has an excellent chance to exceed his strikeout total.

Final Prediction

Everything points toward Boston holding the advantage in the series opener. Suárez has been one of the American League’s most reliable pitchers in 2026, while Mikolas has struggled to produce quality starts consistently. Combined with Fenway Park’s home-field advantage, the Red Sox are well positioned to begin the series with a victory.

Best Bets

• Red Sox Moneyline
• Under 8.5 Runs
• Ranger Suárez Over Strikeouts

Prediction: Red Sox 5, Nationals 2.