The Detroit Tigers travel to Yankee Stadium on Monday, June 29, to begin a three-game series against the New York Yankees in an American League matchup with playoff implications. The opener features a compelling pitching duel between Casey Mize and Ryan Weathers, as both starters look to give their clubs a strong start to the series.

With New York holding one of the best home records in the American League and Detroit continuing to search for consistency, bettors have several appealing wagering opportunities. Here’s a breakdown of the best MLB bets for Tigers vs. Yankees.

Tigers vs. Yankees Starting Pitchers

Detroit is expected to send Casey Mize (2-5, 2.95 ERA) to the mound. While his win-loss record doesn’t reflect it, Mize has been one of the Tigers’ most dependable starters in 2026. He has consistently limited hard contact, worked efficiently through opposing lineups, and kept Detroit competitive despite inconsistent run support. Mize enters Monday with a sub-3.00 ERA and will look to build on another quality outing.

The Yankees counter with left-hander Ryan Weathers (3-5, 3.95 ERA). Weathers has quietly enjoyed a solid campaign, posting 95 strikeouts while giving New York quality innings throughout the first half of the season. Pitching at Yankee Stadium has suited him well, and he’ll benefit from one of baseball’s deepest offensive lineups providing run support.

Best Bet: Yankees Moneyline

Although Mize has pitched better than his record suggests, the Yankees have a significant advantage offensively and enter the series with momentum. New York’s lineup has consistently produced at home, while Detroit has struggled to score against left-handed pitching for stretches this season.

Weathers doesn’t need to dominate if the Yankees’ offense performs to expectations. With home-field advantage and a deeper bullpen, New York is the stronger play on the moneyline.

Best Bet: Yankees Moneyline

Best Total Bet: Under 8 Runs

This matchup has the ingredients for a relatively low-scoring contest. Mize has been excellent at limiting damage, while Weathers has developed into a reliable mid-rotation starter capable of keeping opposing hitters off balance.

Both starters are capable of pitching into the sixth inning, reducing the workload on the bullpens. Unless the Yankees break through late, the under offers solid betting value.

Pick: Under 8 Runs

Best Player Prop

Casey Mize Over Strikeouts

Mize has consistently generated swings and misses against aggressive lineups, and the Yankees remain one of the more strikeout-prone offenses despite their power. If Mize reaches six innings, clearing his strikeout total is a realistic expectation.

Final Prediction

Detroit has the better starting pitcher based on ERA, but New York owns the edge in nearly every other category, including offensive depth, bullpen reliability, and home-field advantage. Expect the Yankees to capitalize on scoring opportunities late and secure the series opener.

Best Bets

• Yankees Moneyline
• Under 8 Runs
• Casey Mize Over Strikeouts

Prediction: Yankees 4, Tigers 2.